Discovery to improve the lives of brain tumor patients
Discovery to improve the lives of brain tumor patients
THE KIM LABORATORY
The Brain Tumor Center
Siteman Cancer Center / WashU Medicine
Taylor Family Department of Neurosurgery
news
New findings and notable events from the Kim lab
UNDERSTANDING GLIOBLASTOMA AND AGGRESSIVE BENIGN BRAIN TUMORS
Glioblastoma is the most common malignant primary brain tumor in adults. Despite aggressive surgical resection, chemotherapy, and radiation therapy, this disease remains challenging with no cure. We are interested in the molecular mechanisms that control key features of glioblastoma biology. The long-term goal of my laboratory is to leverage these insights for the rational design of novel strategies against this formidable disease.
In addition to malignant disease, there is increasing recognition that even benign brain tumors, like meningiomas, pituitary adenomas (also PitNETs), and vestibular schwannomas, can exhibit aggressive behavior and significantly impact the lives of patients. We are thus motivated to identify and understand the features of these brain tumors that might predict aggressive growth and also be targeted therapeutically.
GENETICS
Our laboratory is interested in developing new strategies to accurately profile patient tumors, including multisector and region-specific approaches, utilizing single cell techniques. We are also focused on establishing innovative model systems using canonical tumor mutations.
EPIGENETICS
Therapy resistance is predominantly defined by epigenetic changes in tumor cells. Glioblastoma stem-like cells represent a dynamic and treatment-resistant cell state influenced by cell-intrinsic and -extrinsic cues. Our laboratory is interested in finding ways to disrupt the epigenetic state that defines these tumor-initiating cells. We are pursuing a variety of approaches, including high-throughput screening, pharmacology, biochemistry, genetics, and material engineering, to accomplish this goal.
LASER-BASED IMMUNOTHERAPIES
Laser therapy, also laser interstitial thermal therapy (LITT), is a minimally invasive tool used by neurosurgeons to kill tumor cells. We have established a mouse laser therapy system to examine the ability of LITT to locally disrupt the blood-brain barrier to augment drug delivery. We are particularly interested in how LITT changes the tumor immune microenvironment.
Our Team
The Kim Lab is committed to supporting different viewpoints, experiences, and expertise. We believe that bringing together individuals with varied perspectives drives creativity, discovery, and innovation.
Albert H. Kim, MD, PhD
Principal Investigator
Director, The Brain Tumor Center
Diane Mao, MD
Lab Manager
Loren Beck
Lab Technician
Jason Wong
Staff Scientist
Rajanikanth (Rajani) Vangipurapu
Staff Scientist
Rowland Han, MD
Post-doctoral Fellow
Timothy Woodiwiss, MD
Postdoctoral Fellow
Kyle McGeehan
MD-PhD Student
Co-mentored
with Dr. Alex Stegh
Markus Anzaldua-Campos
MD Student
WashU Medicine
Grace Qi
MD-PhD Student
Co-mentored with Dr. Takeshi Egawa
Ahmad Hammo
MD Student
WashU Medicine
Saara Engineer
Undergraduate Student
WashU
Hong Jin Cao
Undergraduate Student
WashU
Alumni
Undergraduate Students
Alice Turski (2012-2014). Received 2013 Summer Undergraduate Research Fellowship to work in my laboratory: currently a PhD student in English Lnaguage and Literatures, The University of British Columbia
John Finlay (Summer 2015): currently an MD-PhD student at Duke
Simon Gunter (2015-2016): Harvard Medical School, currently a medicine resident at UPenn
Ross Buchman (Summer 2019): currently a medical student at WashU Medicine
Alicia Yang (2020-2022): currently a medical student at Mount Sinai
Day Steed (Summer 2022)
Braxton Sizemore (2021-2023): currently a DVM-PhD student at Cornell University College of Veterinary Medicine
Andrew Hwang (2021-2024): currently a technician at Mass General
Will Leidig (2022-2025): currrently an MD-PhD student at U Cincinnati
Yoon Shin (2023-2025)
Graduate Students
Tatenda Mahlokozera (2020). PhD thesis, MD-PhD program.
Patrick Desouza (2023). PhD thesis, MD-PhD program.
Hao Chen (2023). PhD thesis, Neuroscience program.
Medical Students
Sam Sun (2013-2016). Received the Alpha Omega Alpha Award (2013) and American Brain Tumor Association Summer Fellowship (2014) to work in my lab.
Ishita Chen (Summer 2013).
Diane Aum (2014-2016). Received the David Silbert Summer Research Fellowship to work in my laboratory.
Ramin Lalezari (2014-2016).
David Dadey (2016-2017).
Ioana Flores (2017).
Mounica Pataru (2016-2019). Awarded a NREF Summer Research Fellowship.
Rukayat Taiwo (2017-2019). Awarded a HHMI Medical Fellowship
Sangami Pugazenthi (2021-2025). Awarded multiple fellowships
Post-doctoral Fellows
Amit Gujar, PhD (2012-2017). Currently a Staff Scientist in Roel Verhaak Lab, Jackson Laboratories, CT.
Peter Sylvester, MD (2013-2017). Resident in Neurological Surgery, Washington University.
Ananth Vellimana, MD (2014-2018). Resident in Neurological Surgery, Washington University.
Ashwin Kamath, MD (2014-2018). Resident in Neurological Surgery, Washington University.
Zohny Zohny, MD (2014-2017). Currently a Fellow in Neurological Surgery, Saint Louis University.
Thomas Beaumont, MD (2014-2016).
Rory Murphy, MD (2013-2016).
Santhi Pondugula, PhD (2014-2017).
Brendan Fong, MD (2017-2019)
Afshin Salehi, MD (2017-2020)
Dan Hafez, MD, PhD (2019-2021)
Devi Annamalai, PhD (2016-2020)
Bhuvic Patel, MD (2019-2022)
Satoka Shidoh (2021-2023)
Rui Sun (2020-2023)
Ryan Cleary (2021-2023)
Timothy Woodiwiss (2022-2024), and he's back!
Yiwei Fu (2023-2025)
David Giles (2023-2025)
Publications
2025
1. Chen H, Ferguson CJ, Mitchell DC, Risch I, Titus A, Paulo JA, Hwang A, Beck LK, Lin TH, Gu W, Song SK, Yuede CM, Yano H, Griffith OL, Griffith M, Gygi SP, Bonni A, Kim AH. The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway. Cell Rep. 2025 Feb 25;44(2):115231. doi: 10.1016/j.celrep.2025.115231. Epub 2025 Jan 23. PMID: 39862434; PMCID: PMC11922642.
2. Ishahak M, Han RH, Annamalai D, Woodiwiss T, McCornack C, Cleary RT, DeSouza PA, Qu X, Dahiya S, Kim AH*, Millman JR*. Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression. Adv Sci (Weinh). 2025 Mar;12(10):e2410110. doi: 10.1002/advs.202410110. Epub 2025 Jan 21. PMID: 39836549; PMCID: PMC11905097. *co-corresponding authors.
3. Patel B, Pugazenthi S, English CW, Nitturi V, Pari SS, Mahlokozera T, Leidig WA, Lu HC, Yang A, Roberts K, DeSouza P, McGeehan KP, Mao DD, Sinha N, Ippolito JE, Dahiya S, Petti A, Yano H, Klisch TJ, Harmanci AS, Patel AJ, Kim AH. NF2 loss-of-function and hypoxia drive radiation resistance in grade 2 meningiomas. J Natl Cancer Inst. 2025 Jun 1;117(6):1175-1187. doi: 10.1093/jnci/djaf022. PMID: 39886924; PMCID: PMC12145909.
4. Landazuri P, Cheng JJ, Leuthardt E, Kim AH, Southwell DG, Fecci PE, Neimat J, Sun D, Lega B, Panov F, Chiang V, Abel T, Ben-Haim S, Piccioni DE, Shih JJ, Palys V, Rodriguez A, Bandt SK, Petronio J, Lacroix M, Baumgartner J. Interstitial Thermal Therapy in Mesial Temporal Lobe Epilepsy. JAMA Neurol. 2025 Sep 1;82(9):915-924. doi: 10.1001/jamaneurol.2025.1897. PMID: 40622685; PMCID: PMC12235534.
5. Pugazenthi S, Pari SS, Zhang Z, Silverstein J, Kim AH, Patel B. The evolution and application of multi-omic analysis for pituitary neuroendocrine tumors. Front Med (Lausanne). 2025 Sep 1;12:1629621. doi: 10.3389/fmed.2025.1629621. PMID: 40959438; PMCID: PMC12434087.
6. Klaassen D, Mok S, Hwang JY, Blount SL, Williams KJ, Fong BM, Chicoine MR, Dacey RG, Farrell NF, Osbun JW, Rich KM, Roland LT, Schneider JS, Zipfel GJ, Luo C, Kim AH*, Silverstein JM*. Postoperative fluid restriction to prevent delayed hyponatremia after endoscopic transsphenoidal surgery. Neuro Oncol. 2025 Sep 8;27(7):1746-1757. doi: 10.1093/neuonc/noaf069. PMID: 40084913; PMCID: PMC12417837. *co-corresponding authors.
7. Taghbalout A, Tung CH, Clow PA, Tjong H, Wang P, Wong CH, Mao DD, Maurya R, Huang MF, Ngan CY, Kim AH, Wei CL. Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription. Cancer Cell. 2025 Sep 18:S1535-6108(25)00365-4. doi: 10.1016/j.ccell.2025.08.008. Epub ahead of print. PMID: 40972571.
8. Salcedo-Sifuentes JE, Mehta S, Suryadevara CM, Bergsneider M, Yuen KCJ, Gardner PA, Silverstein JM, Kim AH, Evans JJ, Barkhoudarian G, Fernandez-Miranda JC, Couldwell WT, Rennert RC, Kshettry VR, Wu KC, Benjamin C, Zada G, Chicoine MR, Van Gompel JJ, Catalino MP, Karsy M, Mamelak A, Torok I, Low T, Kim W, Pacione DR, Agrawal N. Development and validation of clinical screening systems for Cushing disease in the United States. Pituitary. 2025 Oct 10;28(6):108. doi: 10.1007/s11102-025-01583-4. PMID: 41071234; PMCID: PMC12513928.
9. Gonzalez-Aponte MF, Huang Y, Leidig WA, Simon T, Butt OH, Ruben MD, Kim AH, Rubin JB, Herzog ED, Walch OJ. Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma. J Neurooncol. 2025 Oct 22;176(1):36. doi: 10.1007/s11060-025-05242-3. PMID: 41123669; PMCID: PMC12546296.
10. Hernandez-Rovira MA, Vagnozzi A, Bales T, Prabhu KN, Niknafs N, Chheda M, Huang J, Kim AH, Miller-Thomas M, Butt O, Vo KD, Sovani BS, Parihar AS, Crumley S, Dahiya S, Mathios D. Diffusely metastatic glioblastoma with FGFR3::TACC3 fusion: cell-free DNA fragmentation analyses and molecular characterization of matched primary and metastatic tumor sites. Acta Neuropathol Commun. 2025 Nov 3;13(1):221. doi: 10.1186/s40478-025-02142-5. PMID: 41185057; PMCID: PMC12581515.
11. DeSouza PA, Ishahak M, Qu X, McCornack C, Annamalai D, Mao DD, Vangipurapu R, Fu Y, Vessoni AT, Cleary RT, Han RH, Augsornworawat P, Woodiwiss T, Agovino D, Sizemore B, Kline J, Borhani-Haghighi M, Chen H, Pugazenthi S, Yano H, Wang T, Batista LFZ, Millman JR,* Kim AH.* INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model. Nat Commun. 2025 Dec 7;17(1):31. doi: 10.1038/s41467-025-66371-x. PMID: 41354838; PMCID: PMC12764576.*co-corresponding authors.
2024
1. Barrett TF, Patel B, Khan SM, Mullins RDZ, Yim AKY, Pugazenthi S, Mahlokozera T, Zipfel GJ, Herzog JA, Chicoine MR, Wick CC, Durakovic N, Osbun JW, Shew M, Sweeney AD, Patel AJ, Buchman CA, Petti AA, Puram SV, Kim AH. Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state. Nat Commun. 2024 Jan 12;15(1):478. doi: 10.1038/s41467-023-42762-w. PMID: 38216553; PMCID: PMC10786875.
2. Kudruk S, Forsyth CM, Dion MZ, Hedlund Orbeck JK, Luo J, Klein RS, Kim AH, Heimberger AB, Mirkin CA, Stegh AH, Artzi N. Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy. Proc Natl Acad Sci U S A. 2024 Feb 20;121(8):e2306973121. doi: 10.1073/pnas.2306973121. Epub 2024 Feb 12. PMID: 38346200; PMCID: PMC10895370.
3. Wang AZ, Mashimo BL, Schaettler MO, Sherpa ND, Leavitt LA, Livingstone AJ, Khan SM, Li M, Anzaldua-Campos MI, Bradley JD, Leuthardt EC, Kim AH, Dowling JL, Chicoine MR, Jones PS, Choi BD, Cahill DP, Carter BS, Petti AA, Johanns TM, Dunn GP. Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population. Cancer Discov. 2024 Feb 28. doi: 10.1158/2159-8290.CD-23-0913. Epub ahead of print. PMID: 38416133.
4. Chiang VL, Pugazenthi S, Leidig WA, Rodriguez A, Prabhu S, Haskell-Mendoza AP, Fecci PE, Placantonakis DG, Abram SR, Lega B, Kim AH. Laser interstitial thermal therapy for new and recurrent meningioma: a prospective and retrospective case series. J Neurosurg. 2024 Mar 8:1-11. doi: 10.3171/2023.12.JNS231542. Epub ahead of print. PMID: 38457795.
5. Johanns TM, Garfinkle EAR, Miller KE, Livingstone AJ, Roberts KF, Rao Venkata LP, Dowling JL, Chicoine MR, Dacey RG, Zipfel GJ, Kim AH, Mardis ER, Dunn GP. Integrating multisector molecular characterization into personalized peptide vaccine design for patients with newly diagnosed glioblastoma. Clin Cancer Res. 2024 Apr 19. doi: 10.1158/1078-0432.CCR-23-3077. Epub ahead of print. PMID: 38639919.
6. Huang J, Campian JL, DeWees TA, Skrott Z, Mistrik M, Johanns TM, Ansstas G, Butt O, Leuthardt E, Dunn GP, Zipfel GJ, Osbun JW, Abraham C, Badiyan S, Schwetye K, Cairncross JG, Rubin JB, Kim AH, Chheda MG. A phase 1/2 study of disulfiram and copper with concurrent radiation therapy and temozolomide for patients with newly diagnosed glioblastoma. Int J Radiat Oncol Biol Phys. 2024 May 18:S0360-3016(24)00660-6. doi: 10.1016/j.ijrobp.2024.05.009. Epub ahead of print. PMID: 38768767.
7. Fu Y, Xu Y, Liu W, Zhang J, Wang F, Jian Q, Huang G, Zou C, Xie X, Kim AH, Mathios D, Pang F, Li F, Wang K, Shen J, Yin J. Tumor-informed deep sequencing of ctDNA detects minimal residual disease and predicts relapse in osteosarcoma. EClinicalMedicine. 2024 Jun 20;73:102697. doi: 10.1016/j.eclinm.2024.102697. PMID: 39022798; PMCID: PMC11252770.
8. Yang PH, Schneider JS, Chicoine MR, Kim AH, Limbrick DD. Endoscopic endonasal optic nerve decompression in children younger than 2 years old with congenital optic canal stenosis: illustrative cases. J Neurosurg Case Lessons. 2024 Jul 8;8(2):CASE23559. doi: 10.3171/CASE23559. PMID: 38976922; PMCID: PMC11284656.
9. Findlay MC, Rennert RC, Lucke-Wold B, Couldwell WT, Evans JJ, Collopy S, Kim W, Delery W, Pacione DR, Kim AH, Silverstein JM, Kanga M, Chicoine MR, Gardner PA, Valappil B, Abdallah H, Sarris CE, Hendricks BK, Torok IE, Low TM, Crocker TA, Yuen KCJ, Vigo V, Fernandez-Miranda JC, Kshettry VR, Little AS, Karsy M. Impact of Frailty on Surgical Outcomes of Patients With Cushing Disease Using the Multicenter Registry of Adenomas of the Pituitary and Related Disorders Registry. Neurosurgery. 2024 Jul 10. doi: 10.1227/neu.0000000000003090. Epub ahead of print. PMID: 38985563.
10. Findlay MC, Rennert RC, Lucke-Wold B, Couldwell WT, Evans JJ, Collopy S, Kim W, Delery W, Pacione DR, Kim AH, Silverstein JM, Kanga M, Chicoine MR, Gardner PA, Valappil B, Abdallah H, Sarris CE, Hendricks BK, Torok IE, Low TM, Crocker TA, Yuen KCJ, Vigo V, Fernandez-Miranda JC, Kshettry VR, Little AS, Karsy M. Impact of Frailty on Surgical Outcomes of Patients With Cushing Disease Using the Multicenter Registry of Adenomas of the Pituitary and Related Disorders Registry. Neurosurgery. 2024 Jul 10. doi: 10.1227/neu.0000000000003090. Epub ahead of print. PMID: 38985563.
11. Little AS, Karsy M, Evans JJ, Kim W, Pacione DR, Kim AH, Gardner PA, Hendricks BK, Sarris CE, Torok IE, Low TM, Crocker TA, Valappil B, Kanga M, Abdallah H, Collopy S, Fernandez-Miranda JC, Vigo V, Ljubimov VA, Zada G, Garrett NE 3rd, Delery W, Yuen KCJ, Rennert RC, Couldwell WT, Silverstein JM, Kshettry VR, Chicoine MR; RAPID Consortium. Multicenter Registry of Adenomas of the Pituitary and Related Disorders: Initial Description of Cushing Disease Cohort, Surgical Outcomes, and Surgeon Characteristics. Neurosurgery. 2024 Aug 1;95(2):372-379. doi: 10.1227/neu.0000000000002888. Epub 2024 Mar 5. PMID: 39008545.
12. Jang HJ, Shah NM, Maeng JH, Liang Y, Basri NL, Ge J, Qu X, Mahlokozera T, Tzeng SC, Williams RB, Moore MJ, Annamalai D, Chen JY, Lee HJ, DeSouza PA, Li D, Xing X, Kim AH*, Wang T*. Epigenetic therapy potentiates transposable element transcription to create tumor-enriched antigens in glioblastoma cells. Nat Genet. 2024 Sep;56(9):1903-1913. doi: 10.1038/s41588-024-01880-x. Epub 2024 Sep 2. PMID: 39223316. *co-corresponding authors.
13. Pugazenthi S, Patel B, English CW, Leidig WA, McGeehan KP, McCornack CR, Mok S, Anzaldua-Campos M, Nouri SH, Roberts K, Chatrath A, Khan A, Gadot R, Yano H, Klisch TJ, Harmanci AS, Patel AJ, Kim AH. Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution. Sci Adv. 2024 Oct 25;10(43):eadn4419. doi: 10.1126/sciadv.adn4419. Epub 2024 Oct 23. PMID: 39441930; PMCID: PMC11498213.
14. Mo CK, Liu J, Chen S, Storrs E, Targino da Costa ALN, Houston A, Wendl MC, Jayasinghe RG, Iglesia MD, Ma C, Herndon JM, Southard-Smith AN, Liu X, Mudd J, Karpova A, Shinkle A, Goedegebuure SP, Abdelzaher ATMA, Bo P, Fulghum L, Livingston S, Balaban M, Hill A, Ippolito JE, Thorsson V, Held JM, Hagemann IS, Kim EH, Bayguinov PO, Kim AH, Mullen MM, Shoghi KI, Ju T, Reimers MA, Weimholt C, Kang LI, Puram SV, Veis DJ, Pachynski R, Fuh KC, Chheda MG, Gillanders WE, Fields RC, Raphael BJ, Chen F, Ding L. Tumour evolution and microenvironment interactions in 2D and 3D space. Nature. 2024 Oct;634(8036):1178-1186. doi: 10.1038/s41586-024-08087-4. Epub 2024 Oct 30. PMID: 39478210; PMCID: PMC11525187.
2023
1. Bowman-Kirigin JA, Desai R, Saunders BT, Wang AZ, Schaettler MO, Liu CJ, Livingstone AJ, Kobayashi DK, Durai V, Kretzer NM, Zipfel GJ, Leuthardt EC, Osbun JW, Chicoine MR, Kim AH, Murphy KM, Johanns TM, Zinselmeyer BH, Dunn GP. The Conventional Dendritic Cell 1 Subset Primes CD8+ T Cells and Traffics Tumor Antigen to Drive Antitumor Immunity in the Brain. Cancer Immunol Res. 2023 Jan 3;11(1):20-37. doi: 10.1158/2326-6066.CIR-22-0098. PMID: 36409838.
3. Coxon AT, Desai R, Patel PR, Vellimana AK, Willie JT, Dowling JL, Leuthardt EC, Kim AH, Johanns TM, Siegel BA, Dunn GP. A pilot study of lymphoscintigraphy with tracer injection into the human brain. J Cereb Blood Flow Metab. 2023 Mar 30:271678X231160891. doi: 10.1177/0271678X231160891. Epub ahead of print. PMID: 36994857.
4. Chan M, Tatter S, Chiang V, Fecci P, Strowd R, Prabhu S, Hadjipanayis C, Kirkpatrick J, Sun D, Sinicrope K, Mohammadi AM, Sevak P, Abram S, Kim AH, Leuthardt E, Chao S, Phillips J, Lacroix M, Williams B, Placantonakis D, Silverman J, Baumgartner J, Piccioni D, Laxton A. Efficacy of laser interstitial thermal therapy for biopsy-proven radiation necrosis in radiographically recurrent brain metastases. Neurooncol Adv. 2023 Mar 28;5(1):vdad031. doi: 10.1093/noajnl/vdad031. PMID: 37114245; PMCID: PMC10129388.
5. Han RH, Johanns TM, Roberts KF, Tao Y, Luo J, Ye Z, Sun P, Blum J, Lin TH, Song SK, Kim AH. Diffusion basis spectrum imaging as an adjunct to conventional MRI leads to earlier diagnosis of high-grade glioma tumor progression versus treatment effect. Neurooncol Adv. 2023 Apr 19;5(1):vdad050. doi: 10.1093/noajnl/vdad050. PMID: 37215950; PMCID: PMC10195207.
6. McCornack C, Woodiwiss T, Hardi A, Yano H, Kim AH. The function of histone methylation and acetylation regulators in GBM pathophysiology. Front Oncol. 2023 May 2;13:1144184. doi: 10.3389/fonc.2023.1144184. PMID: 37205197; PMCID: PMC10185819.
7. Sun R, Han R, McCornack C, Khan S, Tabor GT, Chen Y, Hou J, Jiang H, Schoch KM, Mao DD, Cleary R, Yang A, Liu Q, Luo J, Petti A, Miller TM, Ulrich JD, Holtzman DM, Kim AH. TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Sci Adv. 2023 May 12;9(19):eade3559. doi: 10.1126/sciadv.ade3559. Epub 2023 May 12. PMID: 37172094; PMCID: PMC10181199.
8. Ghosh S, Johanns TM, Chheda MG, Liu E, Butt O, Abraham C, Badiyan S, Huang Y, DeNardo D, Kim AH, Hallahan D, Thotala D, Huang J. A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma. Neurooncol Adv. 2023 Jul 19;5(1):vdad088. doi: 10.1093/noajnl/vdad088. PMID: 37554225; PMCID: PMC10406429.
9. Aghi MK, Brastianos PK, Kim AH, Kalkanis SN, Tonn JC. Introduction. Update on brain metastases. Neurosurg Focus. 2023 Aug;55(2):E1. doi: 10.3171/2023.6.FOCUS23343. PMID: 37527676.
10. Luckett PH, Olufawo M, Lamichhane B, Park KY, Dierker D, Verastegui GT, Yang P, Kim AH, Chheda MG, Snyder AZ, Shimony JS, Leuthardt EC. Predicting survival in glioblastoma with multimodal neuroimaging and machine learning. J Neurooncol. 2023 Sep;164(2):309-320. doi: 10.1007/s11060-023-04439-8. Epub 2023 Sep 5. PMID: 37668941; PMCID: PMC10522528.
11. Terekhanova NV, Karpova A, Liang WW, Strzalkowski A, Chen S, Li Y, Southard-Smith AN, Iglesia MD, Wendl MC, Jayasinghe RG, Liu J, Song Y, Cao S, Houston A, Liu X, Wyczalkowski MA, Lu RJ, Caravan W, Shinkle A, Naser Al Deen N, Herndon JM, Mudd J, Ma C, Sarkar H, Sato K, Ibrahim OM, Mo CK, Chasnoff SE, Porta-Pardo E, Held JM, Pachynski R, Schwarz JK, Gillanders WE, Kim AH, Vij R, DiPersio JF, Puram SV, Chheda MG, Fuh KC, DeNardo DG, Fields RC, Chen F, Raphael BJ, Ding L. Epigenetic regulation during cancer transitions across 11 tumour types. Nature. 2023 Nov;623(7986):432-441. doi: 10.1038/s41586-023-06682-5. Epub 2023 Nov 1. PMID: 37914932; PMCID: PMC10632147.
12. Pugazenthi S, Price M, De La Vega Gomar R, Kruchko C, Waite KA, Barnholtz-Sloan JS, Walsh KM, Kim AH, Ostrom QT. Association of County-Level Socioeconomic Status with Meningioma Incidence and Outcomes. Neuro Oncol. 2023 Dec 13:noad223. doi: 10.1093/neuonc/noad223. Epub ahead of print. PMID: 38087980.
2022
1 Yang PH, Tao Y, Luo J, Paturu M, Lu HC, Ramkissoon S, Heusel JW, Leuthardt EC, Chicoine MR, Dowling JL, Dunn GP, Duncavage E, Dahiya S, Chattherjee AR, Kim AH. Multivariate analysis of associations between clinical sequencing and outcome in glioblastoma. Neurooncol Adv. 2022 Jan 10;4(1):vdac002. doi: 10.1093/noajnl/vdac002. PMID: 35156038; PMCID: PMC8826782.
2. Hwang H, Huang J, Khaddour K, Butt OH, Ansstas G, Chen J, Katumba RG, Kim AH, Leuthardt EC, Campian JL. Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab. CNS Oncol. 2022 Jan 19:CNS81. doi: 10.2217/cns-2021-0013. Epub ahead of print. PMID: 35043686.
3. Patel B, Desai R, Pugazenthi S, Butt OH, Huang J, Kim AH. Identification and Management of Aggressive Meningiomas. Front Oncol. 2022 Mar 23;12:851758. doi: 10.3389/fonc.2022.851758. PMID: 35402234; PMCID: PMC8984123.
4. Johnson GW, Han RH, Smyth MD, Leuthardt EC, Kim AH. Laser Interstitial Thermal Therapy in Grade 2/3 IDH1/2 Mutant Gliomas: A Preliminary Report and Literature Review. Curr Oncol. 2022 Apr 8;29(4):2550-2563. doi: 10.3390/curroncol29040209. PMID: 35448183; PMCID: PMC9028957.
5. Wang AZ, Bowman-Kirigin JA, Desai R, Kang LI, Patel PR, Patel B, Khan SM, Bender D, Marlin MC, Liu J, Osbun JW, Leuthardt EC, Chicoine MR, Dacey RG Jr, Zipfel GJ, Kim AH, DeNardo DG, Petti AA, Dunn GP. Single-cell profiling of human dura and meningioma reveals cellular meningeal landscape and insights into meningioma immune response. Genome Med. 2022 May 10;14(1):49. doi: 10.1186/s13073-022-01051-9. PMID: 35534852; PMCID: PMC9088131.
6. de Groot JF, Kim AH, Prabhu S, Rao G, Laxton AW, Fecci PE, O'Brien BJ, Sloan A, Chiang V, Tatter SB, Mohammadi AM, Placantonakis DG, Strowd RE, Chen C, Hadjipanayis C, Khasraw M, Sun D, Piccioni D, Sinicrope KD, Campian JL, Kurz SC, Williams B, Smith K, Tovar-Spinoza Z, Leuthardt EC. Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma. Neurooncol Adv. 2022 Apr 6;4(1):vdac040. doi: 10.1093/noajnl/vdac040. PMID: 35611270; PMCID: PMC9122789.
7. Mao DD, Cleary RT, Gujar A, Mahlokozera T, Kim AH. CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells. PLoS One. 2022 Jun 23;17(6):e0270251. doi: 10.1371/journal.pone.0270251. PMID: 35737702; PMCID: PMC9223386.
8. Grabowski MM, Srinivasan ES, Vaios EJ, Sankey EW, Otvos B, Krivosheya D, Scott A, Olufawo M, Ma J, Fomchenko EI, Herndon JE, Kim AH, Chiang VL, Chen CC, Leuthardt EC, Barnett GH, Kirkpatrick JP, Mohammadi AM, Fecci PE. Combination laser interstitial thermal therapy plus stereotactic radiotherapy increases time to progression for biopsy-proven recurrent brain metastases. Neurooncol Adv. 2022 Jun 2;4(1):vdac086. doi: 10.1093/noajnl/vdac086. PMID: 35795470; PMCID: PMC9248774.
9. Cross KA, Desai R, Vellimana A, Liu Y, Rich K, Zipfel G, Dacey R, Chicoine M, Klatt-Cromwell C, McJunkin J, Pipkorn P, Schneider JS, Silverstein J, Kim AH. Surgery for Pituitary Tumor Apoplexy Is Associated with Rapid Headache and Cranial Nerve Improvement. Curr Oncol. 2022 Jul 12;29(7):4914-4922. doi: 10.3390/curroncol29070390. PMID: 35877250; PMCID: PMC9319222.
10. Broestl L, Warrington NM, Grandison L, Abou-Antoun T, Tung O, Shenoy S, Tallman MM, Rhee G, Yang W, Sponagel J, Yang L, Kfoury-Beaumont N, Hill CM, Qanni SA, Mao DD, Kim AH, Stewart SA, Venere M, Luo J, Rubin JB. Gonadal sex patterns p21-induced cellular senescence in mouse and human glioblastoma. Commun Biol. 2022 Aug 2;5(1):781. doi: 10.1038/s42003-022-03743-9. PMID: 35918603; PMCID: PMC9345919.
11. Sun R, Kim AH. The multifaceted mechanisms of malignant glioblastoma progression and clinical implications. Cancer Metastasis Rev. 2022 Aug 3. doi: 10.1007/s10555-022-10051-5. Epub ahead of print. PMID: 35920986.
12. Cui Zhou D, Jayasinghe RG, Chen S, Herndon JM, Iglesia MD, Navale P, Wendl MC, Caravan W, Sato K, Storrs E, Mo CK, Liu J, Southard-Smith AN, Wu Y, Naser Al Deen N, Baer JM, Fulton RS, Wyczalkowski MA, Liu R, Fronick CC, Fulton LA, Shinkle A, Thammavong L, Zhu H, Sun H, Wang LB, Li Y, Zuo C, McMichael JF, Davies SR, Appelbaum EL, Robbins KJ, Chasnoff SE, Yang X, Reeb AN, Oh C, Serasanambati M, Lal P, Varghese R, Mashl JR, Ponce J, Terekhanova NV, Yao L, Wang F, Chen L, Schnaubelt M, Lu RJ, Schwarz JK, Puram SV, Kim AH, Song SK, Shoghi KI, Lau KS, Ju T, Chen K, Chatterjee D, Hawkins WG, Zhang H, Achilefu S, Chheda MG, Oh ST, Gillanders WE, Chen F, DeNardo DG, Fields RC, Ding L. Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer. Nat Genet. 2022 Aug 22. doi: 10.1038/s41588-022-01157-1. Epub ahead of print. PMID: 35995947.
13. Li YD, Coxon AT, Huang J, Abraham CD, Dowling JL, Leuthardt EC, Dunn GP, Kim AH, Dacey RG, Zipfel GJ, Evans J, Filiput EA, Chicoine MR. Neoadjuvant stereotactic radiosurgery for brain metastases: a new paradigm. Neurosurg Focus. 2022 Nov;53(5):E8. doi: 10.3171/2022.8.FOCUS22367. PMID: 36321291.
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Photos from lab events
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The Kim Lab
The Brain Tumor Center, Siteman Cancer Center, WashU Medicine
Taylor Family Department of NeurosurgeryJeffrey T. Fort Neuroscience Research Building, 4370 Duncan Ave, Rm 6111, St. Louis, MO 63110Lab (314) 940-6124, Office (314) 747-6561, Fax (314) 362-2107
